Glutathione Reductase (GR) The Scout for Liver Health Hepatic Glucose 6 Phosphate Dehydrogenase (G6PD) plays a pivotal role in the Pentose Phosphate Pathway, generating NADPH for antioxidant defense and supporting nucleotide & amino acid biosynthesis. Pathology of G6PD deficiency Pathology Made Simple The potential link between inherited G6PD deficiency, oxidative stress, and vitamin D deficiency and the racial inequities in mortality associated with COVID 19 ScienceDirect G6PD Deficiency Glucose 6 phosphate dehydrogenase deficiency X linked recessive disorder Leads to low NADPH, impairing glutathione regeneration RBCs are vulnerable to oxidative damage Pathophysiology: In G6PD deficiency: No