Item Long chain fatty acid activation, entry into mitochondria and metabolism via fatty acid oxidation. Public Library of Science Figshare Carnitine Acyltransferase an overview ScienceDirect Topics Short Note On Carnitine Shuttle: Fatty acids are oxidized in mitochondria, and synthesized in the cytoplasm. Long chain fatty acids must form an active intermediate, fatty acyl CoA, before being oxidized inside mitochondria. Catherine The Role of l Carnitine in Mitochondria, Prevention of Metabolic Inflexibility and Disease Initiation Full article: Carnitine: Its Crucial Role in Metabolic Health and Cardiovascular Function